Journals

Editorial introductions.

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Editorial introductions.

Curr Opin Allergy Clin Immunol. 2014 Dec;14(6):v-vi

Authors:

PMID: 25333215 [PubMed - in process]

Reuse of a transplanted liver graft. First experience in South America.

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Reuse of a transplanted liver graft. First experience in South America.

Liver Transpl. 2014 Oct 20;

Authors: Balderramo D, Romero ME, Alcaraz A, Barrabino M, Maraschio M

Abstract

The main limitation of liver transplantation worldwide remains access to an organ associated to the increasing disparity between organ donation and demand. This disparity is also present in Argentina and in other South American countries. Marginal donors are a widely accepted source of organs that attempts to supply the growing demand of organs. Liver graft reuse has been proposed as an alternative organ source in special situations. We report a single case of liver transplantation in a 53-year-old man with alcoholic cirrhosis admitted for grade IV hepatic encephalopathy and type 1 hepatorenal syndrome. The patient received a liver graft from a 65 year-old man transplanted three days earlier due to acute liver failure and who died cerebral hemorrhage and massive brain edema. The liver was implanted with the piggyback technique. During the early postoperative period a biliary leak and hepatic artery stenosis were diagnosed. Both complications were resolved without surgical reintervention. The rest of the postoperative period was uneventful. Two years after the transplant the patient is in good condition with normal liver tests. In countries with long waiting time as Argentina, reuse of transplanted liver graft provides a valid source of organs in selected cases with urgent need for a transplant and low possibilities of survival on the waiting list. Liver Transpl , 2014. © 2014 AASLD.

PMID: 25330761 [PubMed - as supplied by publisher]

Glycemic responses to intermittent hepatic inflow occlusion in living liver donors.

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Glycemic responses to intermittent hepatic inflow occlusion in living liver donors.

Liver Transpl. 2014 Oct 20;

Authors: Han S, Ko JS, Jin SM, Kim JM, Choi S, Joh JW, Chung YH, Lee SK, Gwak M, Kim G

Abstract

The occurrence of glycemic disturbances have been described in patients undergoing intermittent hepatic inflow occlusion (IHIO) for tumor removal. However, the glycemic responses to IHIO in living liver donors are unknown. In the present study, we investigated the glycemic response to IHIO in these patients and examined the association between this procedure and the occurrence of hyperglycemia (blood glucose >180 mg/dl). The data from a total of 154 living donors were retrospectively reviewed. The decision to perform IHIO was made based on the extent of bleeding that occurred during parenchymal dissection. One round of IHIO consisted of 15 minutes of clamping and 5 minutes of unclamping the hepatic artery and portal vein. Blood glucose concentrations were measured at predetermined time points, including the start and end of IHIO. Repeated hyperglycemic episodes occurred following unclamping. The mean maximum intraoperative blood glucose concentration was greater in donors who underwent ≥3 rounds of IHIO than in those who underwent 1-2 rounds of IHIO (169 ± 30 mg/dl versus 149 ± 31 mg/dl, P = 0.005). The incidence of intraoperative hyperglycemia was also greater in donors who underwent ≥3 rounds of IHIO than in those who underwent 1-2 rounds of IHIO (38.7% versus 7.7%, odds ratio 7.1, 95% confidence interval 2.5-20.4, P = 0.001). Donors who did not undergo IHIO and those who underwent 1-2 rounds of IHIO exhibited similar maximum glucose concentrations and similar incidence rates of hyperglycemia. In conclusion, IHIO induced repeated hyperglycemic responses in living donors, and donors who underwent ≥3 rounds of IHIO were more likely to experience intraoperative hyperglycemia. These results provide additional information on the risks and benefits of IHIO in living donors. Liver Transpl , 2014. © 2014 AASLD.

PMID: 25330942 [PubMed - as supplied by publisher]

Management of bleeding and transfusion during liver transplantation before and after the introduction of a ROTEM(®) -based algorithm.

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Management of bleeding and transfusion during liver transplantation before and after the introduction of a ROTEM(®) -based algorithm.

Liver Transpl. 2014 Oct 20;

Authors: Roullet S, Freyburger G, Cruc M, Quinart A, Stecken L, Audy M, Chiche L, Sztark F

Abstract

Orthotopic liver transplantation (OLT) remains a potentially haemorrhagic procedure. Thromboelastometry (ROTEM(®) ) is a point-of-care device used to monitor coagulation during OLT. Whether it allows blood loss and transfusion to be reduced during OLT remains controversial. Excellent correlations and predictive values have been found between ROTEM(®) parameters and fibrinogen. We hypothesized that the use of a ROTEM(®) -based transfusion algorithm during OLT would lead to transfusing more fibrinogen and to decreasing bleeding and blood transfusion. Sixty adult patients were consecutively included in a prospective Without-With study: 30 in the group Without ROTEM(®) results and 30 in the group With ROTEM(®) -based algorithm. A small and non-significant increase in median fibrinogen transfusion was found in the “With” group (6.0 g versus 4.5 g; p=0.50). It was not associated with a decrease in blood transfusion or in the number of patients exposed to blood products. Liver Transpl , 2014. © 2014 AASLD.

PMID: 25331016 [PubMed - as supplied by publisher]

Patient Preferences about Organ Offers in Liver Transplantation.

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Patient Preferences about Organ Offers in Liver Transplantation.

Liver Transpl. 2014 Oct 20;

Authors: Volk ML

PMID: 25332159 [PubMed - as supplied by publisher]

Sofosbuvir, Simeprevir plus Ribavirin for Treatment of HCV Recurrence in HIV-HCV Coinfected Liver Transplant Recipients.

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Sofosbuvir, Simeprevir plus Ribavirin for Treatment of HCV Recurrence in HIV-HCV Coinfected Liver Transplant Recipients.

Liver Transpl. 2014 Oct 20;

Authors: Campos-Varela I, Straley S, Agudelo EZ, Carlson L, Terrault NA

PMID: 25332190 [PubMed - as supplied by publisher]

Highlights.

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Highlights.

JAMA. 2014 Oct 22;312(16):1611-1613

Authors:

PMID: 25335126 [PubMed - as supplied by publisher]

JAMA.

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JAMA.

JAMA. 2014 Oct 22;312(16):1615-1616

Authors:

PMID: 25335127 [PubMed - as supplied by publisher]

No Tomorrow Hath Nor Yesterday: Ina Meares.

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No Tomorrow Hath Nor Yesterday: Ina Meares.

JAMA. 2014 Oct 22;312(16):1618-1619

Authors: Smith JM

PMID: 25335128 [PubMed - as supplied by publisher]

Analysis Reveals Large Increase in Hospitalizations in Recent Years Among Older Patients Prescribed Opioids.

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Analysis Reveals Large Increase in Hospitalizations in Recent Years Among Older Patients Prescribed Opioids.

JAMA. 2014 Oct 22;312(16):1621-1623

Authors: Rubin R

PMID: 25335129 [PubMed - as supplied by publisher]