Evaluation of speech outcomes using English version of the Speech Handicap Index in a cohort of head and neck cancer patients.
Oral Oncol. 2012 Jan 28;
Authors: Dwivedi RC, St Rose S, Chisholm EJ, Bisase B, Amen F, Nutting CM, Clarke PM, Kerawala CJ, Rhys-Evans PH, Harrington KJ, Kazi R
Abstract
The aim of this study was to explore post-treatment speech impairments using English version of Speech Handicap Index (SHI) (first speech-specific questionnaire) in a cohort of oral cavity (OC) and oropharyngeal (OP) cancer patients. Sixty-three consecutive OC and OP cancer patients in follow-up participated in this study. Descriptive analyses have been presented as percentages, while Mann-Whitney U-test and Kruskall-Wallis test have been used for the quantitative variables. Statistical Package for Social Science-15 statistical software (SPSS Inc., Chicago, IL) was used for the statistical analyses. Over a third (36.1%) of patients reported their speech as either average or bad. Speech intelligibility and articulation were the main speech concerns for 58.8% and 52.9% OC and 31.6% and 34.2% OP cancer patients, respectively. While feeling of incompetent and being less outgoing were the speech-related psychosocial concerns for 64.7% and 23.5% OC and 15.8% and 18.4% OP cancer patients, respectively. Worse speech outcomes were noted for oral tongue and base of tongue cancers vs. tonsillar cancers, mean (SD) values were 56.7 (31.3) and 52.0 (38.4) vs. 10.9 (14.8) (P<0.001) and late vs. early T stage cancers 65.0 (29.9) vs. 29.3 (32.7) (P<0.005). The English version of the SHI is a reliable, valid and useful tool for the evaluation of speech in HNC patients. Over one-third of OC and OP cancer patients reported speech problems in their day-do-day life. Advanced T-stage tumors affecting the oral tongue or base of tongue are particularly associated with poor speech outcomes.
PMID: 22289636 [PubMed - as supplied by publisher]
Comparison of the NCI-CTCAE version 4.0 and version 3.0 in assessing chemoradiation-induced oral mucositis for locally advanced nasopharyngeal carcinoma.
Oral Oncol. 2012 Jan 28;
Authors: Liu YJ, Zhu GP, Guan XY
Abstract
To compare the role of CTCAE version 4.0 (v4.0) and version 3.0 (v3.0) in assessing chemoradiation-induced oral mucositis (OM) for locally advanced nasopharyngeal carcinoma (LA-NPC). Patients with LA-NPC were recruited into the study. All eligible participants received docetaxel and cisplatin-based induction chemotherapy followed by intensity modulated radiation therapy concurrent with cisplatin. OM was assessed before and weekly during radiotherapy (RT), using CTCAE v3.0 (clinical exam) and v4.0 separately. OM-related quality of life (QOL) was also evaluated in these patients with the EORTC Quality of Life Questionnaire – Head and Neck module (QLQ-H&N35). From June 2010 to February 2011, 23 eligible patients were enrolled. A highly significant correlation (rho=0.838, p=0.000) and a non-significant difference (p=0.167) in OM grades were found between the two CTCAE versions. However, the trend lines showed that the mean grade determined by CTCAE v3.0 reached a plateau while the mean grade determined by v4.0 continued to increase after the fourth week during RT. Changing trends of several QOL subscale mean scores were similar to that of OM mean grade evaluated by CTCAE v4.0. Both grades of the two CTCAE versions were significantly and positively correlated with scores of several QOL subscales. Nonetheless, the correlation coefficients related to CTCAE v4.0 were higher than those related to v3.0 (rho: 0.727-0.865 versus 0.727-0.778). CTCAE v4.0 could serve as a good surrogate for v3.0 (clinical exam) in assessing chemoradiation-induced oral mucositis. Moreover, CTCAE v4.0 has a few subtle advantages over v3.0 under some circumstances such as delegating QOL. However, there is still no “gold standard” assessment scale for oral mucositis. Therefore, the appropriate tool should be carefully chosen according to the purpose of assessment.
PMID: 22289637 [PubMed - as supplied by publisher]
Herpes Simplex I virus impairs regenerative outcomes of periodontal regenerative therapy in intrabony defects. A pilot study.
J Clin Periodontol. 2012 Jan 7;
Authors: Bertoldi C, Pellacani C, Lalla M, Consolo U, Pinti M, Cortellini P, Cossarizza A
Abstract
AIM: To evaluate the impact of herpesvirus type-1 and -2 on the clinical outcomes of periodontal regenerative procedures in isolated deep intrabony pockets, in an experimental population with no detectable periodontal pathogens. MATERIALS AND METHODS: Seventeen periodontal intraosseous defects in 17 moderate-to-advanced periodontitis patients were treated with regenerative therapy and amelogenins. Microbiological evaluation was performed at baseline (after the completion of initial therapy) and at 1 year to exclude the presence of periodontal pathogens. Herpesviruses-1 and -2 DNA were quantified in the pocket tissues associated to the intrabony defect using molecular assays. Clinical attachment level (CAL), probing pocket depth (PPD) and gingival recession (REC) were recorded at baseline and at 1 year. RESULTS: After 1 year, the 17 defects resulted in significant CAL gain, PPD reduction and REC increase. HSV-1 was detected in five patients. Herpesvirus-2 was never found. The two subpopulations positive or negative to herpesvirus-1 were homogeneous at baseline. At 1 year, the five herpesvirus-1 positive patients resulted in lower amounts of CAL-gain and PPD reduction and greater amount of REC with respect to the 12 herpesvirus-1 negative patients. CONCLUSIONS: The presence of herpesvirus-1 at baseline is associated with poor clinical outcomes following regenerative therapy.
PMID: 22292785 [PubMed - as supplied by publisher]
Serum levels of 25-hydroxyvitamin D, oral health and chronic obstructive pulmonary disease.
J Clin Periodontol. 2012 Jan 7;
Authors: Zhou X, Han J, Song Y, Zhang J, Wang Z
Abstract
AIM: To evaluate the associations of serum 25-Hydroxyvitamin D [25(OH)D] levels with periodontal health and chronic obstructive pulmonary disease (COPD). MATERIAL AND METHODS: We conducted a case-control study of 193 COPD patients and 181 controls. Their periodontal status and lung function were examined, and serum 25(OH)D levels were measured. RESULTS: Mean serum 25(OH)D concentrations were significantly lower in the COPD group than in the controls (32.1 versus 35.8 nmol/l; p = 0.002). Serum 25(OH)D concentrations were positively correlated with lung function among non-smokers and negatively correlated with plaque index (PLI) among former smokers. After adjustment for age, gender, body mass index, season and smoking status, periodontal indexes were significantly associated with serum 25(OH)D concentrations (number of remaining teeth among all groups; probing depth, clinical attachment level, bleeding index, PLI and alveolar bone loss among COPD group). Lower serum 25(OH)D concentrations were significantly associated with an increased risk of COPD among former smokers (Odd ratio 4.11; 95% confidence interval 1.47-11.5; p = 0.007) after adjustment for periodontal indexes and other variables. CONCLUSIONS: Lower serum 25(OH)D concentrations were significantly associated with poor periodontal health and an increased risk of COPD.
PMID: 22296704 [PubMed - as supplied by publisher]
Digitizing implant position locators on master casts: comparison of a noncontact scanner and a contact-probe scanner.
Int J Oral Maxillofac Implants. 2012 Jan;27(1):29-35
Authors: Holst S, Persson A, Wichmann M, Karl M
Abstract
Purpose: Although several investigations of the fit of computer-aided design/computer-assisted manufactured implant restorations have been reported in the literature, very limited information is available on the accuracy of dental scanners for surface data acquisition. The objective of this research project was to investigate the accuracy and repeatability of a three-dimensional noncontact laser scanning system based on conoscopic holography recording the spatial orientation of an implant in vitro. Materials and Methods: One master cast containing five nonparallel implant replicas with scan abutments (implant position locator [IPL], Nobel Biocare) was repeatedly digitized by two commercially available dental scanners and an industrial highprecision coordinate measuring machine as a reference. Repeated measurements of the center point and vector analysis were applied to determine the accuracy and repeatability of IPL orientation. The Wilcoxon signed rank test modified for equivalence was applied to determine whether the systems were equally accurate based on given threshold limits of 0.010, 0.005, and 0.001 mm. Results: All between-system tests identified significant differences, although most differences were very small in absolute terms. Tests for equivalence based on difference windows were exploratorily significant for 0.010 and 0.005 mm. Conclusion: Conoscopic holography scan technology is a valid option to supplement dental touch-probe scanners for laboratory digitization of implant master casts.
Influence of abutment height and surface roughness on in vitro retention of three luting agents.
Int J Oral Maxillofac Implants. 2012 Jan;27(1):36-41
Authors: Cano-Batalla J, Soliva-Garriga J, Campillo-Funollet M, Munoz-Viveros CA, Giner-Tarrida L
Abstract
Purpose: This study evaluated the effects of abutment height, airborne-particle abrasion, and type of cement on the tensile resistance to dislodgement of cement-retained implant restorations. Materials and Methods: Three groups of 12 standardized abutments each were prepared with different heights (4 mm, 5 mm, and 6 mm) using a milling machine. Crowns were cast in cobalt-chrome using the lost-wax technique, airborne particle-abraded using 50-Μm aluminum oxide, and cleaned with acetone. Restorations were cemented using a noneugenol acrylic urethane cement, a resin-modified glass ionomer, or a zinc oxide-noneugenol cement. A 5-kg load was applied for 10 minutes. Samples were kept at 37°C and 100% humidity overnight. A tensile force was applied to the crown using a testing machine at a crosshead speed of 5 mm/minute until failure occurred. Next, the abutments were airborne particle-abraded with 50-Μm aluminum oxide, and the cementation and testing procedures were repeated. The effects of cement, abutment height, and surface treatment were evaluated statistically. Results: There were significant differences among the cements. The resin-modified glass ionomer provided the greatest retention in all the tested conditions, while the zinc oxide-noneugenol cement produced the lowest retention values. Significant differences were also detected between 4-mm and 6-mm abutments, with the 6-mm abutments being more retentive. No differences were found between 4-mm and 5-mm abutments or between 5-mm and 6-mm abutments. The effect of airborne-particle abrasion was also found to be significant. A maximum increase of 90 N in retention force was observed after airborne-particle abrasion for the 5-mm abutments cemented with the acrylic urethane cement. Conclusions: Cement, airborne-particle abrasion, and abutment height can significantly influence retention of implant-supported crowns. Different parameters, including those specific to the patient, should be considered in the selection of a luting agent.
Screw loosening with interchangeable abutments in internally connected implants after cyclic loading.
Int J Oral Maxillofac Implants. 2012 Jan;27(1):42-7
Authors: Kim SK, Koak JY, Heo SJ, Taylor TD, Ryoo S, Lee SY
Abstract
Purpose: The purpose of this study was to observe and compare any loosening of screws attaching several interchangeable abutments to internally connected implants after cyclic loading. Materials and Methods: Four different abutment groups mated with Straumann single-stage transmucosal implants (n = 7 each group) were assessed: Straumann solid abutment, Restore COC abutment, Neoplant solid abutment, and AVANA solid abutment. Each implant was fixed rigidly in a special holding jig. Abutments were tightened to 35 Ncm with a torque controller. A cyclic load of 150 N at a 30-degree angle to the long axis was applied to the implants for 1 million cycles. Prior to loading, Periotest values (PTVs) were measured. After cyclic loading, PTVs were measured and removal torque values (RTVs) of abutments were measured with a digital torque gauge. Results: No mechanical failures were noted for the Straumann solid abutment or the Restore COC abutment. Six Neoplant abutment screws fractured (86%), and four implants fractured (57%) in the group restored with AVANA solid abutments. The RTVs of the Straumann solid abutment were significantly higher than those of the other abutments. The final mean PTV of the Straumann solid abutment was significantly lower than the final mean PTVs of the other abutments. The final mean PTV (4.76 ± 5.58) was significantly higher than the initial mean PTV (-4.29 ± 0.47). Conclusions: Although different abutments are interchangeable with each other, they possess different chemical compositions and physical characteristics. The use of an abutment and implant manufactured by the same company is recommended to prevent the loosening of the abutment screw.
Relationship between subsinus bone height and bone volume requirements for dental implants: a human radiographic study.
Int J Oral Maxillofac Implants. 2012 Jan;27(1):48-54
Authors: Kopecka D, Simunek A, Brazda T, Rota M, Slezak R, Capek L
Abstract
Purpose: To analyze the vertical dimension of subsinus alveolar bone that is available for placement of endosseous implants. Materials and Methods: Subsinus alveolar bone height (SBH) was determined via radiographs and categorized into three groups: Group A corresponded to SBH < 5 mm; group B SBH of 5 to 9 mm; and group C, SBH > 9 mm. Statistical analysis was carried out using the Wilcoxon paired test with the threshold for statistical significance set at P < .05. Results: Five hundred eighty-three panoramic radiographs of edentulous maxillae were analyzed. In 96.9% of radiographs, the anterior border of the maxillary sinus was above the first premolar. Mean SBH values for canine, first premolar, second premolar, first molar, and second molar sites were 11.4 ± 6.2 mm, 10.6 ± 3.8 mm, 5.9 ± 2.5 mm, 3.3 ± 2.2 mm, and 4.5 ± 2.4 mm, respectively. Representations of groups A, B, and C in the canine region were 14.3%, 21.4%, and 64.3%, respectively; in the first premolar region they were 8.3%, 22.3%, and 69.4%, respectively; in the second premolar region, these were 31.6%, 60.9%, and 7.5%, respectively; in first molar region, the values were 73.1%, 25.4%, and 1.5%, respectively; and in the second molar region they were 54.2%, 41.7%, and 4.1%, respectively. Conclusions: The mean SBH is the highest in the area of the anterior border of the sinus; it declines significantly toward the posterior maxilla, reaches its minimum in the area of the first molar, and increases again significantly in the second molar region. From a clinical point of view, the lateral window technique of sinus elevation remains the dominant augmentative procedure in the molar area, whereas in the premolar area, less invasive alternative methods may be more appropriate.
The effect of changes in head position on enlargement of structures during panoramic radiography.
Int J Oral Maxillofac Implants. 2012 Jan;27(1):55-63
Authors: Pfeiffer P, Bewersdorf S, Schmage P
Abstract
Purpose: Accuracy of panoramic radiographs is essential for distance measurements during implant planning, but it might be compromised by various factors. The aim of the present study was to evaluate the effect of vertical and horizontal head positioning on area-dependent enlargement ratios of digital panoramic radiography. Materials and Methods: The mandible of a dry skull was marked with small steel globes. The skull was moved 1 to 4 degrees in 1-degree increments to the left and right and up and down. A series of 17 panoramic radiographs was obtained with the same digital radiographic device. For the rotated skull, horizontal and vertical distances, indicated by the steel globes, were compared to the distances with the ideal positioning of the skull. The results were analyzed statistically. Results: Head positioning and angulation, anatomical site, and distance orientation influenced horizontal measurements. Enlargement ratios of horizontal distances of the right canine and first molar regions (skull rotation to the right 2 to 4 degrees) were significantly lower than those for the corresponding anatomical sites on the left side. Horizontal distance measurements of the different anatomical sites of the left and the right jaw did not differ significantly from each other when the skull was moved downward. When the skull was rotated upward, no significant differences were obtained for corresponding anatomical sites of the right and left arches. Enlargement ratios of vertical distances of different anatomical sites, as well as within the same anatomical site, were not significantly different from each other for the given skull rotations. Conclusions: Ideal head positioning for digital panoramic radiographs is mandatory to avoid improper enlargement ratios of horizontal distances, which can be important in implant dentistry.
PMID: 22299079 [PubMed - in process]
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