Accessory molecules for Toll-like receptors and their function.
Nat Rev Immunol. 2012 Feb 3;
Authors: Lee CC, Avalos AM, Ploegh HL
Abstract
Toll-like receptors (TLRs) are essential components of the innate immune system. Accessory proteins are required for the biosynthesis and activation of TLRs. Here, we summarize recent findings on TLR accessory proteins that are required for cell-surface and endosomal TLR function, and we classify these proteins based on their function as ligand-recognition and delivery cofactors, chaperones and trafficking proteins. Because of their essential roles in TLR function, targeting of such accessory proteins may benefit strategies aimed at manipulating TLR activation for therapeutic applications.
PMID: 22301850 [PubMed - as supplied by publisher]
T cell responses: STAT5 reins in the follicular helpers.
Nat Rev Immunol. 2012 Feb 3;
Authors: Bordon Y
PMID: 22301851 [PubMed - as supplied by publisher]
Antibody responses: Neutrophils zone in to help B cells.
Nat Rev Immunol. 2012;12(2):73
Authors: Bordon Y
PMID: 22266690 [PubMed - in process]
Expanding roles for CD4(+) T cells in immunity to viruses.
Nat Rev Immunol. 2012;12(2):136-48
Authors: Swain SL, McKinstry KK, Strutt TM
Abstract
Viral pathogens often induce strong effector CD4(+) T cell responses that are best known for their ability to help B cell and CD8(+) T cell responses. However, recent studies have uncovered additional roles for CD4(+) T cells, some of which are independent of other lymphocytes, and have described previously unappreciated functions for memory CD4(+) T cells in immunity to viruses. Here, we review the full range of antiviral functions of CD4(+) T cells, discussing the activities of these cells in helping other lymphocytes and in inducing innate immune responses, as well as their direct antiviral roles. We suggest that all of these functions of CD4(+) T cells are integrated to provide highly effective immune protection against viral pathogens.
PMID: 22266691 [PubMed - in process]
Viral immunity: Lose TRAF1, lose control.
Nat Rev Immunol. 2012;12(2):76-7
Authors: Bird L
PMID: 22266692 [PubMed - in process]
Macrophages: Linking lysosome function to macrophage homeostasis.
Nat Rev Immunol. 2012;12(2):74
Authors: Papatriantafyllou M
PMID: 22273766 [PubMed - in process]
T cells: The T(FH)-like transition of T(H)1 cells.
Nat Rev Immunol. 2012;12(2):74-5
Authors: Leavy O
PMID: 22273767 [PubMed - in process]
B cells: Protective role of innate-like B cells in sepsis.
Nat Rev Immunol. 2012;12(2):74
Authors: Bordon Y
PMID: 22273768 [PubMed - in process]
Innate immunity: Phagocytes come back even stronger.
Nat Rev Immunol. 2012;12(2):74
Authors: Leavy O
PMID: 22273769 [PubMed - in process]
Immunometabolism: IL-15 provides breathing space for memory.
Nat Rev Immunol. 2012;12(2):76-7
Authors: Bordon Y
PMID: 22273770 [PubMed - in process]
