Effect of Roux-en-Y gastric bypass on testosterone and prostate-specific antigen.

Effect of Roux-en-Y gastric bypass on testosterone and prostate-specific antigen.

Br J Surg. 2012 Feb 2;

Authors: Woodard G, Ahmed S, Podelski V, Hernandez-Boussard T, Presti J, Morton JM

Abstract

BACKGROUND: Obese men have lower serum levels of testosterone, dehydroepiandrosterone (DHEA) and prostate-specific antigen (PSA), but an increased risk of dying from prostate cancer. The aim of this study was to examine the effect of surgically induced weight loss on serum testosterone, DHEA and PSA levels in obese men. METHODS: Consecutive men undergoing Roux-en-$\font\ss=cmss10 scaled 1000 \hbox{Y}$ gastric bypass (RYGB) participated in a prospective, longitudinal study. Main outcomes were changes were body mass index (BMI), percentage excess weight loss, serum levels of testosterone, DHEA and PSA, PSA mass and plasma volume, measured before operation and 3, 6 and 12 months later. RESULTS: In 64 patients, mean BMI fell from 48·2 kg/m(2) before operation to 39·2, 35·6 and 32·4 kg/m(2) at 3, 6 and 12 months after RYGB. Testosterone levels rose significantly from 259 ng/dl to 386, 452 and 520 ng/dl respectively. Serum PSA levels increased significantly from 0·51 ng/ml to 0·67 ng/ml at 12 months. There were no significant changes in DHEA or PSA mass. CONCLUSION: RYGB normalizes the serum testosterone level. PSA levels increase with weight loss and may be inversely correlated with changes in plasma volume, indicating that PSA levels may be artificially low in obese men owing to haemodilution. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

PMID: 22302466 [PubMed - as supplied by publisher]

 

Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous varicose veins (Br J Surg 2011; 98: 1079-1087).

Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous varicose veins (Br J Surg 2011; 98: 1079-1087).

Br J Surg. 2011 Aug;98(8):1088

Authors: Brittenden J

PMID: 21725958 [PubMed - indexed for MEDLINE]

 



Development of a composite endpoint for randomized controlled trials in liver surgery (Br J Surg 2011; 98: 1138-1145).

Development of a composite endpoint for randomized controlled trials in liver surgery (Br J Surg 2011; 98: 1138-1145).

Br J Surg. 2011 Aug;98(8):1145-6

Authors: de Meijer VE

PMID: 21725959 [PubMed - indexed for MEDLINE]

 

Randomized clinical trial of antibiotics in acute uncomplicated diverticulitis.

Randomized clinical trial of antibiotics in acute uncomplicated diverticulitis.

Br J Surg. 2012 Jan 30;

Authors: Chabok A, Påhlman L, Hjern F, Haapaniemi S, Smedh K,

Abstract

BACKGROUND: The standard of care for acute uncomplicated diverticulitis today is antibiotic treatment, although there are no controlled studies supporting this management. The aim was to investigate the need for antibiotic treatment in acute uncomplicated diverticulitis, with the endpoint of recovery without complications after 12 months of follow-up. METHODS: This multicentre randomized trial involving ten surgical departments in Sweden and one in Iceland recruited 623 patients with computed tomography-verified acute uncomplicated left-sided diverticulitis. Patients were randomized to treatment with (314 patients) or without (309 patients) antibiotics. RESULTS: Age, sex, body mass index, co-morbidities, body temperature, white blood cell count and C-reactive protein level on admission were similar in the two groups. Complications such as perforation or abscess formation were found in six patients (1·9 per cent) who received no antibiotics and in three (1·0 per cent) who were treated with antibiotics (P = 0·302). The median hospital stay was 3 days in both groups. Recurrent diverticulitis necessitating readmission to hospital at the 1-year follow-up was similar in the two groups (16 per cent, P = 0·881). CONCLUSION: Antibiotic treatment for acute uncomplicated diverticulitis neither accelerates recovery nor prevents complications or recurrence. It should be reserved for the treatment of complicated diverticulitis. Registration number: NCT01008488 (http://www.clinicaltrials.gov). Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

PMID: 22290281 [PubMed - as supplied by publisher]

 

Discrete-choice preference comparison between patients and doctors for the surgical management of oesophagogastric cancer (Br J Surg DOI: 10.1002/bjs.7537).

Discrete-choice preference comparison between patients and doctors for the surgical management of oesophagogastric cancer (Br J Surg DOI: 10.1002/bjs.7537).

Br J Surg. 2011 Aug;98(8):1132

Authors: Blazeby JM

PMID: 21674472 [PubMed - indexed for MEDLINE]

 



Effect of injury on S1 dorsal root ganglia in an experimental model of neuropathic faecal incontinence (Br J Surg 2011; 98: 1155-1159) and Sacral nerve stimulation increases activation of the primary somatosensory cortex by anal canal stimulation in an experimental model (Br J Surg 2011; 98: 1160-1169).

Effect of injury on S1 dorsal root ganglia in an experimental model of neuropathic faecal incontinence (Br J Surg 2011; 98: 1155-1159) and Sacral nerve stimulation increases activation of the primary somatosensory cortex by anal canal stimulation in an experimental model (Br J Surg 2011; 98: 1160-1169).

Br J Surg. 2011 Aug;98(8):1170

Authors: Laurberg S

PMID: 21725960 [PubMed - indexed for MEDLINE]

 

A model for rural trauma care.

A model for rural trauma care.

Br J Surg. 2012 Mar;99(3):309-14

Authors: McSwain N, Rotondo M, Meade P, Duchesne J

Abstract

BACKGROUND: In the United States and many other countries, there has been limited attempt to develop a trauma system that addresses the unique trauma situations that occur in rural areas. Rather the planners have attempted to simply extend the urban based trauma system into rural communities. This extension does not address the needs of the majority of patients who are injured in rural communities.

METHODS: A review of the types of patients seen in the rural communities, the volume of these patients and the destination protocols used in the rural communities as taught by the ACS/ATLS and the implications of the CDC Guidelines for Field Triage of Injured Patients Recommendations of the National Expert Panel on Field Triage were reviewed, assessed and compared to the needs in the rural areas for a rural trauma system. In addition, a quality assessment tool was used from a major trauma centre whereby the frequency of patients transported to the centre that were inappropriate for the trauma centre was indicated by the volume that were discharged in 6 h.

RESULTS: Most of the patients injured in the rural communities can be treated in the critical access and rural hospital (> 90 per cent) and can be provided with good care without the need for emergency medical service (EMS) transportation long distances to the trauma centre, inappropriate use of air EMS vehicles thus circumventing families having to travel long distances to see patients, incurring expense and inconvenience, and avoiding loss of revenue to the local hospitals and the overload of urban trauma centres. Rather triage criteria can be taught as per the EMS systems, training given to rural hospital personnel, hospital administrators instructed as to the benefit of such a system, citizens educated as to the advantage of keeping their loved ones closer to home and trauma system registries used to enhance the correct use of the trauma system.

CONCLUSION: Only 5-10 per cent of trauma injuries require the resources of a trauma centre. Proper triage and medical provider education can be used for the benefit of the patient, the EMS system, the rural and urban hospital, and proper quality assurance to assure that the ‘right patient is treated at the right hospital at the right time’, for the benefit of the patient. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

PMID: 22287070 [PubMed - in process]

 

Systematic review and meta-analysis of the effect of North American working hours restrictions on mortality and morbidity in surgical patients (Br J Surg 2012; 99: 336-344).

Systematic review and meta-analysis of the effect of North American working hours restrictions on mortality and morbidity in surgical patients (Br J Surg 2012; 99: 336-344).

Br J Surg. 2012 Mar;99(3):345

Authors: Helling TS

PMID: 22287071 [PubMed - in process]

 

Mass casualty incident training in a resource-limited environment (Br J Surg 2012; 99: 356-361).

Mass casualty incident training in a resource-limited environment (Br J Surg 2012; 99: 356-361).

Br J Surg. 2012 Mar;99(3):361

Authors: Weiser TG

PMID: 22287072 [PubMed - in process]

 

Associated injuries in casualties with traumatic lower extremity amputations caused by improvised explosive devices (Br J Surg 2012; 99: 362-366).

Associated injuries in casualties with traumatic lower extremity amputations caused by improvised explosive devices (Br J Surg 2012; 99: 362-366).

Br J Surg. 2012 Mar;99(3):367

Authors: Holcomb JB

PMID: 22287073 [PubMed - in process]