High prevalence of spa types associated with the clonal lineage CC398 among tetracycline-resistant methicillin-resistant Staphylococcus aureus strains in a Spanish hospital.
J Antimicrob Chemother. 2011 Nov 28;
Authors: Lozano C, Rezusta A, Gómez P, Gómez-Sanz E, Báez N, Martin-Saco G, Zarazaga M, Torres C
Abstract
OBJECTIVES: CC398 (67.3%), CC1 (11.5%), CC5 (11.5%) and CC8 (9.6%). A novel sequence type (ST), ST2077, belonging to CC398 was identified. Most MRSA CC398 strains were typed as SCCmecV-agrI. In addition to β-lactam resistance, isolates showed resistance to (gene/number of strains): tetracycline [tet(K)/36, tet(L)/8 and tet(M)/48], macrolides and lincosamides [erm(B)/6, erm(C)/25, erm(T)/2, msr(A)/msr(B)/4 and mph(C)/4], aminoglycosides [aac(6')-Ie-aph(2')-Ia/8, ant(4')-Ia/13 and aph(3')-IIIa/15], trimethoprim [dfrS1/2 and dfrK/3] and mupirocin (mupA/3). Strains investigated for mutations mediating quinolone resistance revealed an S80F exchange in GrlA and different changes in GyrA. Three strains were Panton-Valentine leucocidin-positive (ST8 and ST94) and 41 strains were cna-positive. All MRSA isolates were negative for the genes tst, eta, etb and etd.ConclusionsTetracycline resistance could be a good marker for MRSA CC398, although this resistance can also be found in other lineages.
PMID: 22127589 [PubMed - as supplied by publisher]
[...] It's the use of antibiotics to wipe out the gut flora so they fatten more quickly that produces MRSA from pigs turning up in humans in hospital Which is why we would be better off eating less intensively reared pasture raised meats rather than [...]