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Use of the HCP5 single nucleotide polymorphism to predict hypersensitivity reactions to abacavir: correlation with HLA-B*5701.
J Antimicrob Chemother. 2010 Jun 9;
Authors: RodrÃguez-Nóvoa S, Cuenca L, Morello J, Córdoba M, Blanco F, Jiménez-Nácher I, Soriano V
Objectives To study the correlation between the HLA-B*5701 allele and the single nucleotide polymorphism in HCP5 (rs2395029). Patients and methods All HIV patients naive for abacavir seen at our institution between September 2007 and December 2008 were prospectively screened for HLA-B*5701. HCP5 rs2395029 genotyping was carried out by allelic discrimination using the TaqMan 5′-nuclease assay. High-resolution HLA class I typing was undertaken using sequence-specific primers. Results A total of 245 HIV patients were included in the study. A good correlation between HLA-B*5701 and HCP5 was observed (negative and positive predictive values of 100% and 93%, respectively). Conclusions The use of HCP5 rs2395029 testing could be as useful as HLA-B*5701 typing to prevent the abacavir hypersensitivity reaction. Given that HCP5 testing is cheaper, less time-consuming and easier to perform than HLA typing, it may confidently replace the latter in clinical settings.
PMID: 20534626 [PubMed - as supplied by publisher]